Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension.

Effect of potassium chloride on the blood pressure in two-kidney, one clip Goldblatt hypertensive rats.

The effects of potassium loading on blood pressure (BP) and the renin-angiotensin-aldosterone system were investigated in two-kidney, one clip Goldblatt hypertensive rats. Two series of experiments were performed: one was begun just after renal artery constriction, and the other, after hypertension had developed. Potassium loading significantly attenuated the development of hypertension, and wa...

The Goldblatt memorial lecture. Part I: Experimental renovascular hyptertension.

Studies on the renal cortical arteries in renovascular hypertension.

Renovascular hypertension is counted among the surgically curable hypertensions, and occupies from 5 to 20per cent of all hypertensions (UENO et al. 1965). Its mechanism is the same as the Goldblatt hypertension (GOLDBLATT et al. 1934), whose vascular lesion can gradually advance, until it becomes refractory to all surgical procedures, if it is left untreated. These circumstances will be greatl...

Amygdala centralis cardiovascular response to angiotensin I microinjection in Goldblatt hypertensive rats

Previous studies have shown that induction of 2kidney -1clip Goldblatt hypertension (2K-1C) induction in rats eliminates hypertensive response after inactivating of the central nucleus of the amygdale (ACe). The present study investigated the possibility of alteration in local renin angiotensin system (RAS) activity in ACe after hypertension induction. Clamps were placed on the left renal arter...

Part II: The Role of the Kidney in Hypertension

These findings led to the clinical recognition of renovascular hypertension, the application of surgery for its relief and the elucidation of the role of the renin-angiotensin system in the physiology of health and the pathogenesis of disease. In the 45 years since Goldblatt's publication on the experimental induction of renovascular hypertension, overwhelmingly conclusive evidence has confirme...